Integrating tumor microenvironment with cancer molecular classifications

Etienne Becht; Aurélien de Reyniès; Wolf H Fridman

doi:10.1186/s13073-015-0241-4

Integrating tumor microenvironment with cancer molecular classifications

Genome Med. 2015 Nov 14;7(1):115. doi: 10.1186/s13073-015-0241-4.

Authors

Etienne Becht^{1

2

3}, Aurélien de Reyniès⁴, Wolf H Fridman^{5

6

7}

Affiliations

¹ INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France.
² Université Paris Descartes, Paris, France.
³ Université Pierre et Marie Curie, Paris, France.
⁴ Programme Cartes d'Identité des Tumeurs, Ligue Nationale Contre le Cancer, Paris, France.
⁵ INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France. [email protected].
⁶ Université Paris Descartes, Paris, France. [email protected].
⁷ Université Pierre et Marie Curie, Paris, France. [email protected].

Abstract

The composition of the tumor microenvironment is associated with a patient's prognosis and can be therapeutically targeted. A link between the cellular composition and genomic features of the tumor and its response to immunotherapy is beginning to emerge. Analyzing the microenvironment of tumor molecular subgroups can be a useful approach to tailor immunotherapies.

MeSH terms

Classification
Humans
Immunogenetics
Neoplasms / classification*
Neoplasms / genetics
Neoplasms / immunology*
Neoplasms / therapy
Prognosis
Tumor Microenvironment / genetics
Tumor Microenvironment / immunology*