Salivary Gland Malignancies

Cristina P Rodriguez; Upendra Parvathaneni; Eduardo Méndez; Renato G Martins

doi:10.1016/j.hoc.2015.08.002

Salivary Gland Malignancies

Hematol Oncol Clin North Am. 2015 Dec;29(6):1145-57. doi: 10.1016/j.hoc.2015.08.002. Epub 2015 Oct 17.

Authors

Cristina P Rodriguez¹, Upendra Parvathaneni², Eduardo Méndez³, Renato G Martins⁴

Affiliations

¹ Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Avenue East, MS G4940, Seattle, WA 98109, USA.
² Division of Radiation Oncology, Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box, Seattle, WA 98195, USA.
³ Department of Otolaryngology, Head and Neck Surgery, University of Washington, 1959 Northeast Pacific Street, Box 356515, Seattle, WA 98195, USA; Clinical Research Division, Fred Hutchinson Cancer Research Center, 1959 Northeast Pacific Street, Box 356515, Seattle, WA 98195, USA.
⁴ Division of Medical Oncology, Department of Medicine, University of Washington, 825 Eastlake Avenue East, MS G4940, Seattle, WA 98109, USA. Electronic address: [email protected].

PMID: 26568553
DOI: 10.1016/j.hoc.2015.08.002

Abstract

Salivary gland malignant tumors represent a diverse group of neoplasms. Their low incidence makes research studies challenging, with most therapeutic recommendations based on case reviews, single-arm trials, or small randomized trials. The standard of care for localized disease is surgical resection. Radiotherapy is the preferred local therapy when surgery is not possible or if there is significant morbidity. When symptomatic metastatic disease develops, systemic therapy is considered. Recent trial accrual success with a cooperative group, treatments based on defined molecular targets, and the development of immunotherapies all hold promise in improving the care of patients with these tumors.

Keywords: Management; Review; Salivary cancer; Systemic; Therapy.

Publication types

Review

MeSH terms

Biopsy
Combined Modality Therapy / methods
Disease Management
Humans
Neoplasm Metastasis
Neoplasm Staging
Research
Salivary Gland Neoplasms / diagnosis*
Salivary Gland Neoplasms / therapy*
Treatment Outcome