The number of pediatric AIDS cases are increasing. This disease, with its social and political ramifications, as well as its biological consequences, presents a number of unique issues for psychologists. Some of the areas that present opportunities and problems for psychologists are briefly identified. These areas include prevention, clinical issues, public education, research, neuropsychological effects, psychoneuroimmunological issues, and ethical concerns. Current epidemiological projections and future directions for research are also discussed.