Improvement of antimicrobial activity of graphene oxide/bacterial cellulose nanocomposites through the electrostatic modification

Carbohydr Polym. 2016 Jan 20:136:1152-60. doi: 10.1016/j.carbpol.2015.10.020. Epub 2015 Oct 13.

Abstract

Graphene oxide (GO) has an attracting and ever-growing interest in various research fields for its fascinating nanostructures. In this study, bacterial cellulose (BC) was used as a matrix to synthesize GO-based materials by a mechanical mixing method. The modification of GO with PEI significantly improved the bonding force between GO nanofillers and BC matrix. The morphology of the nanocomposites had a significant effect on the mechanical properties, hydrophilic properties as well as the antibacterial activity. After the modification, the GO-PEI/BC showed a strong antimicrobial effect on Saccharomyces cerevisiae due to the effective direct contacts between the nanofillers of the composites and the cell surfaces. This study demonstrates that the morphology of the nanocomposites has a great effect on physiochemical properties and the interactions between the microorganism and the nanocomposites.

Keywords: Antimicrobial activity; Bacterial cellulose; Charge modification; Direct contact; Electrostatic interactions; Graphene oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / pharmacology*
  • Cell Membrane Permeability
  • Cellulose / chemistry*
  • Dose-Response Relationship, Drug
  • Drug Stability
  • Gluconacetobacter xylinus / chemistry
  • Graphite / chemistry*
  • Hydrophobic and Hydrophilic Interactions
  • Mechanical Phenomena
  • Microbial Viability / drug effects
  • Nanocomposites / chemistry*
  • Oxides / chemistry*
  • Polyethyleneimine / chemistry
  • Saccharomyces cerevisiae / chemistry
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / physiology
  • Staphylococcus aureus / drug effects
  • Static Electricity*

Substances

  • Anti-Infective Agents
  • Oxides
  • Graphite
  • Polyethyleneimine
  • Cellulose