We have studied retrospectively the presence of serologic markers of type 1 and type 2 human immunodeficiency virus infection in 102 subjects coming from West Africa and living in Catalonia. We have proven the presence of specific antibodies to type 2 human immunodeficiency virus in three asymptomatic subjects among whose epidemiologic antecedents the unique risk factor was heterosexual promiscuity. These three subjects are the first seropositive to type 2 human immunodeficiency virus reported in our country. In none of the studied cases serologic markers of type 1 human immunodeficiency virus infection were detected.