Abstract
In mouse embryos, the int-1 proto-oncogene is transiently expressed in areas of the developing neural system. Retinoic acid-treated P19 embryonal carcinoma cells have often been used as an in vitro model for the molecular basis of neural development. We shown here that int-1 is transiently expressed in differentiated P19 cells. The time course and retinoic acid dose dependence of int-1 expression suggest that the gene is specifically expressed during early neural differentiation. P19 cells may be a useful model to assist in the study, at the cellular level, of the role of int-1 in neural development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / drug effects
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Gene Expression Regulation / drug effects
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Neurons / drug effects
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Neurons / metabolism
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Neurons / pathology
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Proto-Oncogene Proteins / biosynthesis
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Proto-Oncogene Proteins / genetics
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Proto-Oncogenes* / drug effects
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Teratoma / genetics*
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Teratoma / metabolism
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Teratoma / pathology
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Tretinoin / pharmacology
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / metabolism
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Tumor Cells, Cultured / pathology
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Wnt Proteins
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Wnt1 Protein
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Zebrafish Proteins*
Substances
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Proto-Oncogene Proteins
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Wnt Proteins
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Wnt1 Protein
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Zebrafish Proteins
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Tretinoin