Abstract
To better understand underlying causes of lower rotavirus vaccine effectiveness in low-middle income countries (LMICs), we measured innate antiviral factors in Nicaraguan mothers' milk and immune response to the first dose of the pentavalent rotavirus vaccine in corresponding infants. No relationship was found between concentrations of innate factors and rotavirus vaccine response.
Keywords:
Nicaragua; breast milk; innate immunity; lactadherin; lactoferrin; rotavirus vaccines.
© The Author 2015. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: [email protected].
MeSH terms
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Developing Countries
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Female
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / immunology*
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Humans
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Immunity, Innate / immunology*
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Immunogenicity, Vaccine / immunology
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Infant
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Male
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Milk, Human / immunology*
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Nicaragua
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Poliovirus Vaccine, Inactivated / administration & dosage
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Poliovirus Vaccine, Inactivated / immunology*
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Treatment Outcome
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / immunology
Substances
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Pentavac
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Poliovirus Vaccine, Inactivated
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Vaccines, Combined