Abstract
This commentary highlights new findings from a recent study identifying adipose tissue as a potential HIV reservoir and a major site of inflammation during chronic human/simian immunodeficiency virus (HIV/SIV) infection. A concise discussion about upcoming challenges and new research avenues for reducing chronic adipose inflammation during HIV/SIV infection is presented.
Keywords:
CD4/CD8 T-cell; HIV/SIV reservoir; adipose tissue; inflammation; macrophage.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adipose Tissue / immunology*
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Adipose Tissue / pathology
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Adipose Tissue / virology
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Animals
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CD4-Positive T-Lymphocytes / virology
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CD8-Positive T-Lymphocytes / virology
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HIV / genetics
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HIV / immunology*
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HIV Infections / immunology*
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HIV Infections / virology
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Humans
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Inflammation / virology
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Macaca mulatta / virology
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Macrophages / virology
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Simian Acquired Immunodeficiency Syndrome / immunology*
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology*
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Viral Load
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Virus Replication