Abstract
We report a case of a 76-year-old female with multiple lung nodules (Fig. 1 Rx). Pathologic evaluation of the lower left video-assisted thoracoscopic surgery (VATS) lobectomy VATS-lobectomy showed four nodules that were described as pulmonary epithelioid hemangio-endothelioma (PEH); the immunohistochemical stains showed that the neoplastic cells expressed CD31, a variable expression for factor VIII and a low expression of CD34. In the remaining parenchyma of the lobe, multiple nests of neuroendocrine cells were observed with immunohistochemical confirmation, and the diagnosis was diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). To our knowledge, the association between PEH and DIPNECH has never been described in the literature.
MeSH terms
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Aged
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Biomarkers, Tumor / analysis
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Biopsy
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Female
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Hemangioendothelioma, Epithelioid / chemistry
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Hemangioendothelioma, Epithelioid / diagnostic imaging
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Hemangioendothelioma, Epithelioid / pathology*
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Hemangioendothelioma, Epithelioid / surgery
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Humans
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Hyperplasia
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Immunohistochemistry
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Lung Neoplasms / chemistry
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / pathology*
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Lung Neoplasms / surgery
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Multiple Pulmonary Nodules / chemistry
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Multiple Pulmonary Nodules / diagnostic imaging
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Multiple Pulmonary Nodules / pathology*
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Multiple Pulmonary Nodules / surgery
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Neuroendocrine Cells / chemistry
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Neuroendocrine Cells / pathology*
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Pneumonectomy / methods
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Precancerous Conditions / chemistry
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Precancerous Conditions / diagnostic imaging
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Precancerous Conditions / pathology*
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Precancerous Conditions / surgery
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Predictive Value of Tests
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Thoracic Surgery, Video-Assisted
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Tomography, X-Ray Computed
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Treatment Outcome