Abstract
The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Apoptosis
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Cataract / enzymology
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Cataract / genetics*
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Cataract / pathology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Eye / growth & development
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Eye / metabolism*
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Eye Proteins / genetics
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Eye Proteins / metabolism
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Gene Expression Regulation, Developmental
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Glaucoma / enzymology
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Glaucoma / genetics*
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Glaucoma / pathology
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Goldfish
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Heat Shock Transcription Factors
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism
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Humans
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Organogenesis / genetics
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PAX6 Transcription Factor
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Paired Box Transcription Factors / genetics
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Paired Box Transcription Factors / metabolism
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Protein Phosphatase 1 / genetics*
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Protein Phosphatase 1 / metabolism
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Protein Phosphatase 2 / genetics*
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Protein Phosphatase 2 / metabolism
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Protein Subunits / genetics*
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Protein Subunits / metabolism
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Repressor Proteins / genetics
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Repressor Proteins / metabolism
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Signal Transduction
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Transcription Factors / genetics
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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Eye Proteins
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HSF4 protein, human
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Heat Shock Transcription Factors
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Homeodomain Proteins
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Isoenzymes
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PAX6 Transcription Factor
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PAX6 protein, human
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Paired Box Transcription Factors
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Protein Subunits
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Repressor Proteins
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Transcription Factors
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Protein Phosphatase 1
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Protein Phosphatase 2