Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

H Cheloufi; B Belhani; T S Ouk; R Zerrouki; N-E Aouf; M Berredjem

doi:10.1007/s11030-015-9647-6

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

Mol Divers. 2016 May;20(2):399-405. doi: 10.1007/s11030-015-9647-6. Epub 2015 Nov 23.

Authors

H Cheloufi¹, B Belhani¹, T S Ouk², R Zerrouki², N-E Aouf¹, M Berredjem³

Affiliations

¹ Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria.
² Laboratoire de Chimie des Substances Naturelles, Université de Limoges, 123 Av. Albert Thomas, 87060, Limoges Cedex, France.
³ Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji-Mokhtar, Annaba University, BOX 12, Annaba, Algeria. [email protected].

PMID: 26597910
DOI: 10.1007/s11030-015-9647-6

Abstract

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a-m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Keywords: Antitumor; Cancer; Nitrogen mustard; Sulfonamides; Sulfonylcycloureas.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Mechlorethamine / chemistry*
Structure-Activity Relationship
Urease / chemical synthesis*
Urease / chemistry
Urease / pharmacology*

Substances

Antineoplastic Agents
Mechlorethamine
Urease