Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

Org Lett. 2015 Dec 4;17(23):5934-7. doi: 10.1021/acs.orglett.5b03230. Epub 2015 Nov 24.

Abstract

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120 °C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.

Publication types

  • Research Support, Non-U.S. Gov't