Abstract
Combinations of various factors of polypogenesis determine the formation of a mixed structural phenotype of urethral polyps consisting of heterogeneous changes of the epithelium (hyperplasia, metaplasia, and erosions), inflammatory cell infiltration of the stroma, and dilatation of the venous plexus vessels. Urogenital infections are associated with the predominance of symptoms of inflammation, high serum levels of IL-1β and TNF-α, more extensive areas of inflammatory infiltration and subepithelial microvascular bed, predominance of hyperemic form of microcirculatory disorders. The combination of hyperplastic reactions of the epithelial layer with neoangiogenesis and myofibroblast proliferation in the subepithelial zone confirms the key role of dysregeneratory hyperplasia in the mechanisms of polypogenesis.
Keywords:
laser Doppler flowmetry; pathomorphology; ureaplasma; urethral polyp; urogenital infections.
MeSH terms
-
Chlamydia Infections / complications
-
Chlamydia Infections / microbiology
-
Chlamydia trachomatis / isolation & purification
-
Epithelial Cells / pathology
-
Female
-
Humans
-
Hyperplasia
-
Inflammation
-
Interleukin-1beta / blood
-
Interleukin-4 / blood
-
Menopause
-
Metaplasia
-
Microcirculation
-
Middle Aged
-
Mycoplasma Infections / complications
-
Mycoplasma Infections / microbiology
-
Mycoplasma genitalium / isolation & purification
-
Myofibroblasts / pathology
-
Neovascularization, Pathologic / etiology
-
Neovascularization, Pathologic / pathology
-
Phenotype
-
Polyps / blood
-
Polyps / complications
-
Polyps / pathology*
-
Stromal Cells / pathology
-
Trichomonas Infections / complications
-
Trichomonas Infections / microbiology
-
Trichomonas vaginalis / isolation & purification
-
Tumor Necrosis Factor-alpha / analysis
-
Ureaplasma Infections / complications
-
Ureaplasma Infections / microbiology
-
Ureaplasma urealyticum / isolation & purification
-
Urethral Neoplasms / blood
-
Urethral Neoplasms / blood supply
-
Urethral Neoplasms / complications
-
Urethral Neoplasms / pathology*
-
Urinary Tract Infections / complications
Substances
-
Interleukin-1beta
-
Tumor Necrosis Factor-alpha
-
Interleukin-4