Successful Use of Temocillin as Salvage Therapy for Cervical Osteomyelitis Secondary to Multidrug-Resistant Burkholderia cepacia

Marcela Rodriguez; Miranda Nelson; James E Kelly; Alexis Elward; Sharon Celeste Morley

doi:10.1093/jpids/pis110

Successful Use of Temocillin as Salvage Therapy for Cervical Osteomyelitis Secondary to Multidrug-Resistant Burkholderia cepacia

J Pediatric Infect Dis Soc. 2014 Mar;3(1):77-80. doi: 10.1093/jpids/pis110. Epub 2013 Jan 8.

Authors

Marcela Rodriguez¹, Miranda Nelson², James E Kelly³, Alexis Elward², Sharon Celeste Morley²

Affiliations

¹ Department of Pediatrics, Southern Illinois University School of Medicine, Springfield; and Departments of [email protected].
² Pediatrics.
³ Radiology, Washington University School of Medicine, St Louis, Missouri.

PMID: 26624908
DOI: 10.1093/jpids/pis110

Abstract

Infection with multidrug resistant Burkholderia cepacia presents a therapeutic challenge in patients with cystic fibrosis. In this study, we present a case of progressive cervical osteomyelitis secondary to B cepacia that failed surgical drainage and extended therapy with meropenem, piperacillin-tazobactam, doxycycline, and aminoglycosides. Temocillin (Negaban) was successfully used to clear the infection.

Keywords: Burkholderia cepacia; cystic fibrosis; multidrug-resistant; vertebral osteomyelitis.