[Short bowel syndrome and intestinal failure - new developments]

Dtsch Med Wochenschr. 2015 Dec;140(24):1842-4. doi: 10.1055/s-0041-107970. Epub 2015 Dec 1.
[Article in German]

Abstract

Intestinal failure is characterized by intestinal water and electrolyte losses as well as malabsorption of macronutrients. It often requires individually composed parenteral support (so call compounding). Teduglutide, a DPP-IV resistant GLP2 analogue, is available a pharmacologic treatment, which stimulates intestinal absorption and can facilitate infusion free days. Catheter infections are the most common complication of home parenteral support. The incidence can be minimized using Taurolidin as a catheter block solution.

Publication types

  • Review

MeSH terms

  • Catheter-Related Infections / etiology
  • Catheter-Related Infections / prevention & control
  • Evidence-Based Medicine
  • Humans
  • Intestinal Diseases / diagnosis
  • Intestinal Diseases / etiology
  • Intestinal Diseases / therapy*
  • Malabsorption Syndromes / diagnosis
  • Malabsorption Syndromes / etiology
  • Malabsorption Syndromes / therapy*
  • Parenteral Nutrition, Total* / adverse effects
  • Peptides / adverse effects
  • Peptides / therapeutic use*
  • Short Bowel Syndrome / diagnosis
  • Short Bowel Syndrome / etiology
  • Short Bowel Syndrome / therapy*
  • Water-Electrolyte Imbalance / diagnosis
  • Water-Electrolyte Imbalance / etiology
  • Water-Electrolyte Imbalance / therapy*

Substances

  • Peptides
  • teduglutide