An ultrasound system has been developed which uses high-frequency (20 MHz) ultrasound to provide high-resolution images of tissue. The system provides 0.21-mm range and 0.65-mm lateral resolution. The transducer aperture size is 1.8 mm maximum. Miniature probes have been developed which can image via the biopsy channels of standard fiberoptic endoscopes as well as probes for imaging in vitro. A commercially available video "frame grabber" is used in conjunction with a standard microcomputer for image acquisition. This allows images to be displayed and recorded on standard television equipment and be stored and manipulated digitally. The features of the system allow in vivo imaging, in vitro imaging after resection, and histological images of the same tissue region to be acquired and compared. This method is particularly useful in learning how to correctly interpret ultrasonic images of the intestinal wall. The use of 20 MHz is advantageous in achieving excellent resolution and small size probes. The system provides a unique approach to imaging the intestinal wall.