Multifunctional Nanostructures for Tumor-Targeted Molecular Imaging and Photodynamic Therapy

Adv Healthc Mater. 2016 Feb 4;5(3):311-8. doi: 10.1002/adhm.201500668. Epub 2015 Dec 2.

Abstract

A multifunctional ICG-FA-PPD nanostructure is constructed by a facile self-assembly method through the negatively charged indocyanine green (ICG)- and positively charged folic acid-modified PEI-PEG-gadoteric acid (FA-PPD). The resulting ICG-FA-PPD is not only able to be used for targeting tumors, magnetic resonance imaging (MRI), and near-infrared imaging, but, more importantly, it enables photodynamic therapy for tumor.

Keywords: imaging; magnetic resonance imaging; multifunctional nanoprobes; near-infrared imaging; photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Folic Acid / chemistry
  • Humans
  • Indocyanine Green / chemistry
  • Magnetic Resonance Imaging / methods
  • Molecular Imaging / methods
  • Nanostructures / administration & dosage*
  • Nanostructures / chemistry*
  • Neoplasms / therapy*
  • Photochemotherapy / methods
  • Polyethylene Glycols / chemistry
  • Polyethyleneimine / analogs & derivatives
  • Polyethyleneimine / chemistry

Substances

  • poly(ethylene glycol)-co-poly(ethyleneimine)
  • Polyethylene Glycols
  • Polyethyleneimine
  • Folic Acid
  • Indocyanine Green