Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing

Chem Commun (Camb). 2016 Jan 25;52(7):1413-5. doi: 10.1039/c5cc06937h.

Abstract

A catalytic self-assembled DNA dendritic complex was herein reported and used for siRNA-based gene silencing. This kind of one-pot DNA dendrimer can be conveniently prepared as needed, and it was demonstrated to have better silencing efficiency and lower cytotoxicity than commercial cationic lipid transfection agents.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • DNA / chemistry
  • DNA / genetics*
  • Electrophoresis, Agar Gel
  • Flow Cytometry
  • Gene Silencing*
  • Microscopy, Confocal
  • RNA, Small Interfering / genetics

Substances

  • RNA, Small Interfering
  • DNA