Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats

Yan Zhang; Tao Hu; Hongli Zhou; Yang Zhang; Gang Jin; Yu Yang

doi:10.1016/j.ijbiomac.2015.11.045

Antidiabetic effect of polysaccharides from Pleurotus ostreatus in streptozotocin-induced diabetic rats

Int J Biol Macromol. 2016 Feb:83:126-32. doi: 10.1016/j.ijbiomac.2015.11.045. Epub 2015 Nov 25.

Authors

Yan Zhang¹, Tao Hu², Hongli Zhou³, Yang Zhang³, Gang Jin³, Yu Yang⁴

Affiliations

¹ School of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, PR China. Electronic address: [email protected].
² Endocrinology Department, General Hospital of CNPC in Jilin, Jilin 132021, PR China.
³ School of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, PR China.
⁴ Clinical Laboratory, General Hospital of CNPC in Jilin, Jilin 132021, PR China.

PMID: 26627601
DOI: 10.1016/j.ijbiomac.2015.11.045

Abstract

This study was performed to evaluate the effects of total polysaccharides extracted from Pleurotus ostreatus on type 2 diabetes. Rats were administered with high-fat diet and streptozotocin (STZ) to induce diabetes. The rats were then treated with 100, 200, and 400 mg/kg/d POP or vehicle for 4 weeks. Our experiments indicated that POP reduces hyperglycemia and hyperlipidemia levels, improves insulin resistance, and increases glycogen storage by activating GSK3 phosphorylation and GLUT4 translocation. Moreover, POP reduces the risk of oxidative damage by increasing superoxide dismutase(SOD), catalase(CAT), and glutathione peroxidase(GSH-Px) activities and decreasing malonaldehyde(MDA) level. These results suggest that POP exerts antidiabetic effect on STZ-induced diabetic rats.

Keywords: Hyperglycemia; Hyperlipidemia; Insulin resistance; Pleurotus ostreatus; Polysaccharides; Type 2 diabetes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antioxidants / metabolism
Blood Glucose / drug effects
Blood Glucose / metabolism
Catalase / metabolism
Diabetes Mellitus, Experimental / chemically induced
Diabetes Mellitus, Experimental / drug therapy
Diabetes Mellitus, Experimental / metabolism
Diabetes Mellitus, Type 2 / chemically induced
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / metabolism
Diet, High-Fat / adverse effects
Glutathione / metabolism
Glutathione Peroxidase / metabolism
Glycogen Synthase Kinase 3 / metabolism
Hyperglycemia / drug therapy
Hyperglycemia / metabolism
Hyperlipidemias / drug therapy
Hyperlipidemias / metabolism
Hypoglycemic Agents / pharmacology*
Male
Malondialdehyde / metabolism
Oxidative Stress / drug effects
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Pleurotus / chemistry*
Polysaccharides / pharmacology*
Rats
Rats, Wistar
Streptozocin / pharmacology
Superoxide Dismutase / metabolism

Substances

Antioxidants
Blood Glucose
Hypoglycemic Agents
Plant Extracts
Polysaccharides
Malondialdehyde
Streptozocin
Catalase
Glutathione Peroxidase
Superoxide Dismutase
Glycogen Synthase Kinase 3
Glutathione