ESWL using the HM3 Dornier lithotriptor is a new therapeutic method for cystine stone disease, particularly in patients who have undergone several surgical procedures with or without adjuvant dissolving drugs. We report 3 cases, demonstrating satisfactory fragmentation results. However the rate of stone-free patients was much lower. This situation might be improved by the adjuvant use of dissolving drugs. The preliminary results (Feb 1988) of the European multicenter study (61 cases in 10 centers), confirm our own experience with a 90% fragmentation rate and only 30% stone-free rate for kidney stones and 77% for ureteral stones.