Lack of association between FOXO1 polymorphisms and bacteremia

Increasing evidence suggests that FOXO1, one critical gene related to the human immune system, probable is closely to the human infection. In the present study we aimed to investigate genetic association of FOXO1 with bacteremia in Han Chinese. 188 patients with bacteremia diagnosed with blood culture and 250 healthy blood donors without signs of infection were studied, two tagging SNPs of FOXO1 (rs9532571, rs3751436) were selected and genotyped using predesigned TaqMan allelic discrimination assays. The results showed that the allele frequency of rs9532571 and rs3751436 in FOXO1 was not associated with an increased risk of bacteremia (P=0.762, OR=1.05, 95% CI 0.77-1.43; P=0.059, OR=1.34, 95% CI 0.99-1.81 respectively), the genotype distribution of these two SNPs was also not significantly different between bacteremia patients and control groups (P=0.9; P=0.16). Haplotypes in this block were not significantly associated with bacteremia risk.

Conclusion: the association between FOXO1 genetic polymorphism and bacteremia has not been observed in the study, maybe a larger sample population and more SNPs in the FOXO1 need to reveal the role in bacteremia in the future.