Intravenous immunoglobulin in acute Sydenham's chorea: A systematic review

Shekeeb S Mohammad; Margherita Nosadini; Padraic Grattan-Smith; Russell C Dale

doi:10.1111/jpc.12915

Intravenous immunoglobulin in acute Sydenham's chorea: A systematic review

J Paediatr Child Health. 2015 Dec;51(12):1235-8. doi: 10.1111/jpc.12915.

Authors

Shekeeb S Mohammad¹, Margherita Nosadini^{1

2}, Padraic Grattan-Smith³, Russell C Dale^{1

3}

Affiliations

¹ Neuroimmunology Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.
² Paediatric Neurology Unit, Department of Paediatrics, University of Padua, Italy.
³ TY Nelson Department of Neurology and Neurosurgery, The Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.

PMID: 26633611
DOI: 10.1111/jpc.12915

Abstract

Sydenham's chorea (SC) is a major manifestation seen in 25% of patients with acute rheumatic fever. SC is the prototypic autoimmune neurological disorder, which has a less appreciated associated risk of psychiatric morbidity. We undertook a systematic review to examine whether the use of intravenous immunoglobulin affects clinical recovery and morbidity.

Keywords: behavioural; developmental; general paediatrics; immunology; neurology.

Publication types

Case Reports
Review
Systematic Review

MeSH terms

Acute Disease
Adolescent
Chorea / diagnosis
Chorea / drug therapy*
Female
Humans
Immunoglobulins, Intravenous / therapeutic use*
Rheumatic Fever / diagnosis
Treatment Outcome

Substances

Immunoglobulins, Intravenous