The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation

Haematologica. 2016 Mar;101(3):e72-6. doi: 10.3324/haematol.2015.135459. Epub 2015 Dec 3.
No abstract available

Keywords: LXR; ectosomes; extracellular vesicles; inflammation; microvesicles; plasmacytoid dendritic cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter 1 / genetics
  • ATP Binding Cassette Transporter 1 / immunology
  • Angiogenic Proteins / genetics
  • Angiogenic Proteins / immunology
  • Benzoates / pharmacology
  • Benzylamines / pharmacology
  • Blood Platelets / cytology
  • Blood Platelets / drug effects
  • Blood Platelets / immunology*
  • Cell-Derived Microparticles / chemistry
  • Cell-Derived Microparticles / immunology*
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology*
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Endothelial Cells / immunology
  • Gene Expression Regulation
  • Humans
  • Hydrocarbons, Fluorinated / pharmacology
  • Hydroxycholesterols / pharmacology
  • Imidazoles / pharmacology
  • Immunity, Innate
  • Liver X Receptors / agonists
  • Liver X Receptors / antagonists & inhibitors
  • Liver X Receptors / genetics
  • Liver X Receptors / immunology*
  • NF-kappa B / genetics
  • NF-kappa B / immunology
  • Oligodeoxyribonucleotides / genetics
  • Oligodeoxyribonucleotides / immunology
  • Phenylenediamines / pharmacology
  • Primary Cell Culture
  • Receptors, G-Protein-Coupled
  • Signal Transduction
  • Sterol Regulatory Element Binding Protein 1 / genetics
  • Sterol Regulatory Element Binding Protein 1 / immunology
  • Sulfonamides / pharmacology
  • Toll-Like Receptor 7 / antagonists & inhibitors
  • Toll-Like Receptor 7 / genetics
  • Toll-Like Receptor 7 / immunology
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine
  • ABCA1 protein, human
  • ADGRB1 protein, human
  • ATP Binding Cassette Transporter 1
  • Angiogenic Proteins
  • Benzoates
  • Benzylamines
  • CPG-oligonucleotide
  • GW 3965
  • Hydrocarbons, Fluorinated
  • Hydroxycholesterols
  • Imidazoles
  • Liver X Receptors
  • NF-kappa B
  • NR1H3 protein, human
  • Oligodeoxyribonucleotides
  • Phenylenediamines
  • Receptors, G-Protein-Coupled
  • SREBF1 protein, human
  • Sterol Regulatory Element Binding Protein 1
  • Sulfonamides
  • T0901317
  • TLR7 protein, human
  • Toll-Like Receptor 7
  • Tumor Necrosis Factor-alpha
  • 22-hydroxycholesterol
  • resiquimod