More Frequent than Desired: Midgut Stem Cell Somatic Mutations

Cell Stem Cell. 2015 Dec 3;17(6):639-640. doi: 10.1016/j.stem.2015.11.011.

Abstract

The accumulation of somatic mutations in adult stem cells contributes to the decline of tissue functions and cancer initiation. In this issue of Cell Stem Cell, Siudeja et al. (2015) investigate the rate and mechanism of naturally occurring mutations in Drosophila midgut intestinal stem cells during aging and find high-frequency mutations arising from multiple mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adult Stem Cells / metabolism*
  • Animals
  • Drosophila / genetics*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / metabolism
  • Intestinal Mucosa / metabolism
  • Mutation
  • Signal Transduction / genetics
  • Stem Cells / metabolism

Substances

  • Drosophila Proteins