Effects of combination treatment with sirolimus and mitotane on growth of human adrenocortical carcinoma cells

Endocrine. 2016 Jun;52(3):664-7. doi: 10.1007/s12020-015-0818-0. Epub 2015 Dec 8.

Authors

Maria Cristina De Martino¹, Peter M van Koetsveld¹, Richard A Feelders¹, Steven W J Lamberts¹, Wouter W de Herder¹, Annamaria Colao², Rosario Pivonello², Leo J Hofland³

Affiliations

¹ Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands.
² Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Uniniversità Federico II di Napoli, Via S. Pansini 5, 80131, Naples, Italy.
³ Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. [email protected].

PMID: 26645813
DOI: 10.1007/s12020-015-0818-0

No abstract available

Publication types

Letter

MeSH terms

Adrenal Cortex Neoplasms / pathology*
Adrenocortical Carcinoma / pathology*
Antineoplastic Agents, Hormonal / administration & dosage*
Cell Line, Tumor
Cell Proliferation / drug effects*
Dose-Response Relationship, Drug
Humans
Mitotane / administration & dosage
Mitotane / pharmacology*
Sirolimus / administration & dosage
Sirolimus / pharmacology*

Substances

Antineoplastic Agents, Hormonal
Mitotane
Sirolimus