Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

D Popa; L Loewenstein; S W Lam; E A Neuner; C L Ahrens; A Bhimraj

doi:10.1016/j.jhin.2015.10.017

Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

J Hosp Infect. 2016 Feb;92(2):199-202. doi: 10.1016/j.jhin.2015.10.017. Epub 2015 Nov 6.

Authors

D Popa¹, L Loewenstein², S W Lam², E A Neuner², C L Ahrens², A Bhimraj³

Affiliations

¹ Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA. Electronic address: [email protected].
² Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
³ Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH, USA.

PMID: 26654472
DOI: 10.1016/j.jhin.2015.10.017

Abstract

Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.

Keywords: Intraventricular; Meningitis; Therapeutic drug monitoring; Vancomycin; Ventriculitis.

MeSH terms

Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / analysis*
Anti-Bacterial Agents / pharmacokinetics*
Cerebrospinal Fluid / chemistry*
Drug Monitoring*
Female
Humans
Injections, Intraventricular
Male
Meningitis, Bacterial / drug therapy*
Middle Aged
Retrospective Studies
Vancomycin / analysis*
Vancomycin / pharmacokinetics*

Substances

Anti-Bacterial Agents
Vancomycin