Abstract
The performance of an assay to detect antibodies to a norovirus nonstructural fusion protein, designated VPR and consisting of three proteins (GI.1 virus protein genome-linked [VPg], a virus protease, and an RNA-dependent RNA polymerase), was evaluated. The assay sensitivity and specificity were 74.5% and >95%, respectively, for identifying GI.1 norovirus infection among persons who received either a monovalent GI.1 norovirus virus-like particle (VLP) vaccine or placebo by the intranasal route followed by an oral live GI.1 norovirus challenge.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Intranasal
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Antibodies, Viral / blood*
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Antibodies, Viral / immunology
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Caliciviridae Infections / diagnosis
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Caliciviridae Infections / immunology*
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Caliciviridae Infections / virology
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Feces / virology
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Humans
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Immunoassay
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Norovirus / chemistry
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Norovirus / immunology*
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Sensitivity and Specificity
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Vaccines, Virus-Like Particle / administration & dosage
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Vaccines, Virus-Like Particle / immunology
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Viral Fusion Proteins / immunology
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Viral Nonstructural Proteins / immunology*
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Viral Vaccines / administration & dosage*
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Viral Vaccines / immunology*
Substances
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Antibodies, Viral
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Vaccines, Virus-Like Particle
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Viral Fusion Proteins
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Viral Nonstructural Proteins
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Viral Vaccines