Systemic and renal haemodynamic effects of renin or angiotensin converting enzyme inhibition in non-human primates

J Hypertens Suppl. 1989 Apr;7(2):S43-6. doi: 10.1097/00004872-198904002-00010.

Abstract

The cardiovascular actions of a renin inhibitor, U-71038 (Boc-Pro-Phe-N-MeHis-Leu psi [CHOHCH2]Val-Ile-Amp), and of an angiotensin converting enzyme (ACE) inhibitor, captopril, were determined in conscious sodium-depleted cynomolgus monkeys. Cardiac output was measured with a thermodilution technique. The hypotension induced by U-71038 was associated with a significant reduction in total peripheral resistance without alteration in cardiac output or the heart rate. A similar reduction in total peripheral resistance was observed after captopril at a dose which caused hypotension equivalent to that elicited by U-71038. The latter effects were not accompanied by significant alterations in cardiac output or the heart rate. The glomerular filtration rate was measured by the plasma disappearance of 125I-sodium iothalamate. Renin or ACE inhibition adequate to cause equivalent hypotensive responses did not change the glomerular filtration rate to a significantly different degree. The systemic and renal haemodynamic profiles of U-71038 and captopril appear to be similar, suggesting that renin and ACE inhibition elicit fundamentally similar cardiovascular effects in conscious sodium-depleted cynomolgus monkeys via a decreased formation of angiotensin II (Ang II).

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Captopril / pharmacology*
  • Glomerular Filtration Rate / drug effects
  • Hemodynamics / drug effects*
  • Kidney / blood supply
  • Kidney / drug effects*
  • Kidney / physiology
  • Macaca fascicularis
  • Male
  • Oligopeptides / pharmacology*
  • Renin / antagonists & inhibitors*
  • Sodium / deficiency

Substances

  • Oligopeptides
  • ditekiren
  • Captopril
  • Sodium
  • Renin