SEOM guidelines for the management of Malignant Melanoma 2015

Clin Transl Oncol. 2015 Dec;17(12):1030-5. doi: 10.1007/s12094-015-1450-4. Epub 2015 Dec 15.

Abstract

All melanoma patients must be confirmed histologically and resected according to Breslow. Sentinel node biopsy must be done when tumor is over 1 mm or if less with high-risk factors. Adjuvant therapy with interferon must be offered for patients with high-risk melanoma and in selected cases radiotherapy can be added. Metastatic melanoma treatment is guided by mutational BRAF status. BRAF wild type patients must receive anti-PD1 therapy and BRAF mutated patients BRAF/MEK inhibitors or anti-PD1 therapy. Up to 10 years follow up is recommended for melanoma patients with dermatologic examinations and physical exams.

Keywords: Adjuvant; Immunotherapy; Melanoma; Metastatic; b-raf.

MeSH terms

  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Disease Management
  • Early Detection of Cancer
  • Humans
  • Medical Oncology
  • Melanoma / diagnosis*
  • Melanoma / therapy*
  • Neoplasm Staging
  • Practice Guidelines as Topic / standards*
  • Prognosis
  • Societies, Medical