Bladder Leiomyosarcoma 25 Years after Treatment with Cyclophosphamide in Patient with History of Retinoblastoma

Urol Int. 2018;100(1):119-121. doi: 10.1159/000437442. Epub 2015 Dec 17.

Abstract

The objective of this case report is to present a rare bladder tumour in a young patient 25 years after the treatment with cyclophosphamide because of a neuroblastoma of the right eye. The first symptom of the tumour was macroscopic haematuria with dysuria and pollakiuria. The final diagnosis was dictaminated by the pathologist and the best treatment option was radical cystoprostatectomy. Leiomyosarcoma was presented in a 26-year-old patient like the third different tumour, the second was an esphenoidal meningioma. At the 8th year of follow-up after the radical surgery, the patient is free of bladder disease. Bladder leiomyosarcoma is a rare tumour of the bladder and its early diagnosis and treatment are mandatory for best prognosis.

Keywords: Bladder leiomyosarcoma; Cyclophosphamide; Cystectomy; Retinoblastoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Humans
  • Leiomyosarcoma / diagnosis*
  • Leiomyosarcoma / surgery
  • Male
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / surgery
  • Retinal Neoplasms / therapy
  • Retinoblastoma / therapy
  • Time Factors
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / surgery

Substances

  • Antineoplastic Agents, Alkylating
  • Cyclophosphamide