Antiviral benzofurans from Eupatorium chinense

Phytochemistry. 2016 Feb:122:238-245. doi: 10.1016/j.phytochem.2015.11.013. Epub 2015 Dec 7.

Abstract

Eleven benzofuran dimers, (+)-dieupachinins A-E, (-)-dieupachinins A-E and dieupachinin F, a benzofuran trimer trieupachinin A, as well as seven known compounds were isolated from the roots of Eupatorium chinense. The enantiomers of racemates dieupachinins A-E were separated by chiral HPLC. The structures with absolute configurations were elucidated on the basis of spectroscopic data, X-ray diffraction analysis, and circular dichroism experiments. The isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus (RSV).

Keywords: Antiviral activity; Benzofuran; Chinese folk medicine; Compositae; Eupatorium chinense.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology*
  • Chromatography, High Pressure Liquid
  • Eupatorium / chemistry*
  • Molecular Structure
  • Plant Roots / chemistry
  • Respiratory Syncytial Viruses / drug effects*

Substances

  • Antiviral Agents
  • Benzofurans