Proliferation of functional human natural killer cells with anti-HIV-1 activity in NOD/SCID/Jak3(null) mice

Microbiol Immunol. 2016 Feb;60(2):106-13. doi: 10.1111/1348-0421.12355.

Abstract

Natural killer cells, a critical component of the innate immune system, eradicate both virus-infected cells and tumor cells through cytotoxicity and secretion of cytokines. Human NK cell research has largely been based on in vitro studies because of the lack of appropriate animal models. In this study, a selective proliferation model of functional human NK cells was established in NOD/SCID/Jak3(null) (NOJ) mice transplanted with peripheral blood mononuclear cells (PBMC) and K562 cells. The antiviral effects of NK cells were evaluated by challenging this mouse model with HIV-1. The percentage of intracellular p24(+) T cells and the amount of plasma p24 was decreased compared with NOJ mice transplanted with PBMC. Our findings indicate that NK cells have an anti-HIV-1 effect through direct cytotoxicity against HIV-1-infected cells. These mice provide an important model for evaluating human NK function against human infectious diseases such as HIV-1 and malignancies.

Keywords: HIV-1; innate immunity; mouse model; natural killer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Proliferation* / physiology
  • Cells, Cultured
  • Cord Blood Stem Cell Transplantation / methods
  • Cytotoxicity, Immunologic
  • Disease Models, Animal*
  • HIV Core Protein p24 / immunology
  • HIV Infections / blood
  • HIV Infections / immunology*
  • HIV Infections / therapy
  • HIV Infections / virology
  • HIV-1 / immunology*
  • Humans
  • Immunity, Innate
  • Immunotherapy, Adoptive / methods
  • K562 Cells
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / transplantation*
  • Leukocytes, Mononuclear / immunology
  • Leukocytes, Mononuclear / transplantation
  • Lymphocyte Activation / immunology
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • T-Lymphocytes / immunology

Substances

  • HIV Core Protein p24