Recurrent Staphylococcus aureus abscess and fatal pneumococcal septicemia due to IRAK-4 deficiency

Pediatr Int. 2015 Dec;57(6):1166-9. doi: 10.1111/ped.12722.

Abstract

We describe the case of an infant with recurrent episodes of staphylococcal skin abscess and subsequent lethal pneumococcal meningitis/septicemia due to interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency. In this case, systemic signs of inflammatory response were poor and delayed. Among all other reported cases of IRAK-4 deficiency, none involved severe viral or fungal disease, and the range of infecting bacteria was narrow.

Keywords: IRAK-4 deficiency; delayed systemic signs of inflammatory response; pneumococcal meningitis/septicemia; staphylococcal skin abscess.

Publication types

  • Case Reports

MeSH terms

  • Abscess / complications*
  • Abscess / diagnosis
  • Abscess / microbiology
  • Fatal Outcome
  • Female
  • Follow-Up Studies
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / diagnosis
  • Infant
  • Interleukin-1 Receptor-Associated Kinases
  • Meningitis, Pneumococcal / complications*
  • Meningitis, Pneumococcal / diagnosis
  • Meningitis, Pneumococcal / microbiology
  • Primary Immunodeficiency Diseases
  • Sepsis / diagnosis
  • Sepsis / etiology*
  • Sepsis / microbiology
  • Staphylococcal Infections / complications*
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / isolation & purification*

Substances

  • Interleukin-1 Receptor-Associated Kinases

Supplementary concepts

  • IRAK4 Deficiency