Complete resolution of minocycline pigmentation following a single treatment with non-ablative 1550-nm fractional resurfacing in combination with the 755-nm Q-switched alexandrite laser

Lasers Surg Med. 2016 Mar;48(3):234-7. doi: 10.1002/lsm.22463. Epub 2015 Dec 30.

Abstract

Pigmentation secondary to minocycline ingestion is an uncommon adverse event affecting 3.7-14.8% of treated individuals for which few effective therapies are available. Three patterns of minocycline pigmentation have a characteristic clinical and histological appearance. The pigment composition in each variety is different and occurs at varying skin depths. Accordingly, a tailored approach according to the type of minocycline pigmentation is crucial for treatment success. The purpose of this intervention was to evaluate the efficacy of non-ablative fractional photothermolysis in combination with the Q-switched alexandrite laser for the treatment of type I minocycline pigmentation on the face. A patient with type I minocycline pigmentation was treated with non-ablative 1550-nm fractional photothermolysis followed immediately by 755-nm Q-switched alexandrite laser and then observed clinically to determine the outcome of this modality. The patient was seen in clinic 1 month later following her single treatment session and 100% clearance of all blue facial pigment was observed. Non-ablative fractional photothermolysis in combination with the 755-nm Q-switched alexandrite laser should be considered for treatment of type I minocycline pigmentation.

Keywords: Q-switched alexandrite laser; minocycline pigmentation; non-ablative 1550-nm fractional photothermolysis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Female
  • Humans
  • Hyperpigmentation / chemically induced
  • Hyperpigmentation / surgery*
  • Lasers, Solid-State / therapeutic use*
  • Middle Aged
  • Minocycline / adverse effects*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Minocycline