Plasmalyte: No Longer a Culprit in Causing False-Positive Galactomannan Test Results

Isabel Spriet; Katrien Lagrou; Johan Maertens; Ludo Willems; Alexander Wilmer; Joost Wauters

doi:10.1128/JCM.02813-15

Plasmalyte: No Longer a Culprit in Causing False-Positive Galactomannan Test Results

J Clin Microbiol. 2016 Mar;54(3):795-7. doi: 10.1128/JCM.02813-15. Epub 2015 Dec 30.

Authors

Isabel Spriet¹, Katrien Lagrou², Johan Maertens³, Ludo Willems⁴, Alexander Wilmer⁵, Joost Wauters⁵

Affiliations

¹ Pharmacy Department, University Hospitals Leuven, Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, University of Leuven, Leuven, Belgium [email protected].
² Clinical Department of Laboratory Medicine, University Hospitals Leuven, Department of Microbiology and Immunology, Laboratory for Clinical Bacteriology and Mycology, University of Leuven, Leuven, Belgium.
³ Hematology Department, University Hospitals Leuven, Department of Microbiology and Immunology, Laboratory for Clinical Bacteriology and Mycology, University of Leuven, Leuven, Belgium.
⁴ Pharmacy Department, University Hospitals Leuven, Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, University of Leuven, Leuven, Belgium.
⁵ Medical Intensive Care Unit, University Hospitals Leuven, Department of Microbiology and Immunology, Laboratory for Clinical Infectious and Inflammatory Diseases, University of Leuven, Leuven, Belgium.

Abstract

False-positive galactomannan (GM) results have been reported in patients treated with gluconate-containing solutions, such as Plasmalyte. The GM optical density index was tested on 33 distinct batches of Plasmalyte and was found to be negative in all of the batches, confirming that Plasmalyte is no longer a cause of false-positive GM results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Fungal / blood
Antigens, Fungal / immunology
Aspergillosis / blood
Aspergillosis / diagnosis
Aspergillosis / microbiology
Biomarkers
Electrolytes / administration & dosage
Electrolytes / adverse effects*
False Positive Reactions*
Galactose / analogs & derivatives
Humans
Immunoenzyme Techniques / methods
Immunoenzyme Techniques / standards
Mannans / blood*
Mannans / immunology

Substances

Antigens, Fungal
Biomarkers
Electrolytes
Mannans
galactomannan
Galactose

Grants and funding

I.S. and J.W. are funded by the Clinical Research Foundation, University Hospitals Leuven, Belgium. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.