Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples

Leuk Lymphoma. 2016 Aug;57(8):1938-41. doi: 10.3109/10428194.2015.1110747. Epub 2016 Jan 4.

Authors

Benjamin Y Lu¹, Shivani U Thanawala², Kelly C Zochowski², Michael J Burke³, William L Carroll², Teena Bhatla²

Affiliations

¹ a Perlmutter Cancer Center , New York University Langone Medical Center , New York , NY , USA ; Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA ;
² b Perlmutter Cancer Center , New York University Langone Medical Center , New York , NY , USA ;
³ c Division of Hematology/Oncology/Blood and Marrow Transplant, Department of Pediatrics , Medical College of Wisconsin and Children's Hospital of Wisconsin , Milwaukee , WI , USA.

PMID: 26726842
DOI: 10.3109/10428194.2015.1110747

No abstract available

Publication types

Letter

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / pharmacology*
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Azacitidine / administration & dosage
Azacitidine / analogs & derivatives*
Azacitidine / pharmacology
Basic Helix-Loop-Helix Transcription Factors / genetics
Cell Line, Tumor
Cell Survival / drug effects
Cell Survival / genetics
Decitabine
Drug Synergism
Gene Expression Regulation, Leukemic / drug effects
Humans
Jurkat Cells
Mice
Neoplasm Proteins / genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology
Receptors, Interleukin-7 / genetics
Reverse Transcriptase Polymerase Chain Reaction
Xenograft Model Antitumor Assays*

Substances

Antineoplastic Agents
Basic Helix-Loop-Helix Transcription Factors
LYL1 protein, human
Neoplasm Proteins
Receptors, Interleukin-7
Decitabine
Azacitidine