Monoclonal antibody immunoassay in the study of thrombogenicity of preclotted and gelatin-impregnated aortic prostheses

Ann Vasc Surg. 1989 Jul;3(3):248-50. doi: 10.1016/S0890-5096(07)60033-8.

Abstract

The Dimertest Enzyme Immunoassay has been used to compare the degree of thrombogenicity of the standard knitted Dacron prosthesis (n = 10) and the gelatin-impregnated Dacron prosthesis (n = 10) after infrarenal aortic reconstruction. After surgery there was a similar rise in cross-linked fibrin degradation products with both types of prostheses. Although on the third day the D-Dimer level in the gelatin-impregnated prosthesis was lower, there was no significant difference in the D-Dimer level at six weeks. This suggests that the potential risk of thrombogenicity in the gelatin-impregnated prosthesis is similar to the standard preclotted type.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • Aorta, Abdominal / surgery*
  • Blood Vessel Prosthesis / adverse effects*
  • Clinical Enzyme Tests*
  • Female
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Thrombosis / blood
  • Thrombosis / diagnosis*
  • Thrombosis / etiology

Substances

  • Antibodies, Monoclonal
  • Fibrin Fibrinogen Degradation Products