Synthesis, lipophilicity and antimicrobial activity evaluation of some new thiazolyl-oxadiazolines

Background and aims: Synthesis of new potential antimicrobial agents and evaluation of their lipophilicity.

Methods: Ten new thiazolyl-oxadiazoline derivatives were synthesized and their structures were validated by 1H-NMR and mass spectrometry. The lipophilicity of the compounds was evaluated using the principal component analysis (PCA) method. The necessary data for applying this method were obtained by reverse-phase thin-layer chromatography (RP-TLC). The antimicrobial activities were tested in vitro against four bacterial strains and one fungal strain.

Results: The lipophilicity varied with the structure but could not be correlated with the antimicrobial activity, since this was modest.

Conclusions: We have synthesized ten new heterocyclic compounds. After their physical and chemical characterization, we determined their lipophilicity and screened their antimicrobial activity.