Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

Antiviral Res. 2016 Feb:126:69-80. doi: 10.1016/j.antiviral.2015.12.011. Epub 2015 Dec 29.

Abstract

Influenza A viruses (IAVs) impact the public health and global economy by causing yearly epidemics and occasional pandemics. Several anti-IAV drugs are available and many are in development. However, the question remains which of these antiviral agents may allow activation of immune responses and protect patients against co- and re-infections. To answer to this question, we analysed immuno-modulating properties of the antivirals saliphenylhalamide (SaliPhe), SNS-032, obatoclax, and gemcitabine, and found that only gemcitabine did not impair immune responses in infected cells. It also allowed activation of innate immune responses in lipopolysaccharide (LPS)- and interferon alpha (IFNα)-stimulated macrophages. Moreover, immuno-mediators produced by gemcitabine-treated IAV-infected macrophages were able to prime immune responses in non-infected cells. Thus, we identified an antiviral agent which might be beneficial for treatment of patients with severe viral infections.

Keywords: Antiviral agents; Immune responses; Influenza A virus; Innate immunity; Virus-host interaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / pharmacology
  • Antineoplastic Agents / pharmacology*
  • Antiviral Agents / pharmacology*
  • Cells, Cultured
  • Coinfection / drug therapy
  • Coinfection / virology
  • Cytokines / metabolism
  • Deoxycytidine / analogs & derivatives
  • Deoxycytidine / pharmacology
  • Gemcitabine
  • Humans
  • Immunity, Innate / drug effects
  • Immunologic Factors / pharmacology*
  • Indoles
  • Influenza A virus / drug effects
  • Influenza A virus / physiology
  • Influenza, Human / drug therapy*
  • Influenza, Human / immunology
  • Influenza, Human / virology
  • Interferon-alpha / drug effects
  • Interferon-alpha / immunology
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Macrophages / virology*
  • Oxazoles / pharmacology
  • Phosphoproteins / metabolism
  • Pyrroles / pharmacology
  • RNA, Viral / biosynthesis
  • Salicylates / pharmacology
  • Thiazoles / pharmacology
  • Virus Replication / drug effects
  • Virus Replication / physiology

Substances

  • Amides
  • Antineoplastic Agents
  • Antiviral Agents
  • Cytokines
  • Immunologic Factors
  • Indoles
  • Interferon-alpha
  • Lipopolysaccharides
  • N-(5-(((5-(1,1-dimethylethyl)-2-oxazolyl)methyl)thio)-2-thiazolyl)-4-piperidinecarboxamide
  • Oxazoles
  • Phosphoproteins
  • Pyrroles
  • RNA, Viral
  • Salicylates
  • Thiazoles
  • saliphenylhalamide
  • Deoxycytidine
  • obatoclax
  • Gemcitabine