Wavelength-selective light-triggered strand exchange reaction

K Morihiro; T Kodama; S Mori; S Tsunoda; S Obika

doi:10.1039/c5ob02369f

Wavelength-selective light-triggered strand exchange reaction

Org Biomol Chem. 2016 Feb 7;14(5):1555-8. doi: 10.1039/c5ob02369f.

Authors

K Morihiro¹, T Kodama², S Mori³, S Tsunoda⁴, S Obika¹

Affiliations

¹ Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. [email protected] and National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.
² Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8601, Japan.
³ Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. [email protected].
⁴ National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

PMID: 26739866
DOI: 10.1039/c5ob02369f

Abstract

We prepared an oligodeoxynucleotide (ODN) bearing two 4-hydroxy-2-mercaptobenzimidazole nucleobase analogues (SB(NV) and SB(NB)) modified with different photolabile groups. This ODN enabled a light-triggered strand exchange reaction in a wavelength-selective manner.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Light*
Molecular Structure
Oligodeoxyribonucleotides / chemical synthesis*
Oligodeoxyribonucleotides / chemistry

Substances

Oligodeoxyribonucleotides