Abstract
The efficacy and safety of two combination drugs, consisting of a diuretic + a K-sparing agent, were investigated in the treatment of essential hypertension. A double-blind, randomized, parallel group study design was employed. After randomization, 14 patients were treated with 10 mg xipamide + 30 mg triamterene (A) and 16 with 25 mg hydrochlorothiazide + 50 mg triamterene (B). The patients suffered from essential hypertension with a systolic blood pressure (SBP) at entry of greater than or equal to 150 mmHg and a diastolic blood pressure (DBP) of greater than or equal to 95 mmHg. After 6 weeks, mean decline in DBP was 12% in group A and 9% in group B, respectively. With treatment A, one patient became hypokalemic and with treatment B one patient became hyperkalemic.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Blood Pressure / drug effects
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Cholesterol / blood
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Clinical Trials as Topic
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Diuretics / administration & dosage
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Diuretics / adverse effects
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Diuretics / therapeutic use*
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Double-Blind Method
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Drug Therapy, Combination
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Female
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Humans
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Hydrochlorothiazide / administration & dosage
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Hydrochlorothiazide / adverse effects
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Hydrochlorothiazide / therapeutic use*
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Hypertension / drug therapy*
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Hypertension / physiopathology
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Male
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Middle Aged
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Potassium / blood
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Random Allocation
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Triamterene / administration & dosage
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Triamterene / adverse effects
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Triamterene / therapeutic use*
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Triglycerides / blood
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Uric Acid / blood
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Xipamide / administration & dosage
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Xipamide / adverse effects
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Xipamide / therapeutic use*
Substances
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Diuretics
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Triglycerides
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Hydrochlorothiazide
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Uric Acid
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Xipamide
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Cholesterol
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Potassium
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Triamterene