Coexistence of blaOXA-23 with armA in quinolone-resistant Acinetobacter baumannii from a Chinese university hospital

Diagn Microbiol Infect Dis. 2016 Mar;84(3):230-1. doi: 10.1016/j.diagmicrobio.2015.10.009. Epub 2015 Oct 23.

Abstract

A total of 101 Acinetobacter baumannii isolates were collected to determine the mechanisms of quinolone resistance and investigate the occurrence of carbapenem and high-level aminoglycoside resistance genes among quinolone-resistant strains. Among 77 quinolone-resistant A. baumannii harbored mutations of gyrA and parC, 41 isolates, which belonged to European clone II, had resistance to aminoglycosides and carbapenems due to the expression of armA and acquisition of blaOXA-23. Most of sequence type belonged to clonal complex 92. These results suggested hospital dissemination of multidrug-resistant A. baumannii carrying blaOXA-23, armA, and mutations of quinolone resistance-determining regions in western China.

Keywords: Acinetobacter baumannii; Multi-drug resistant; Quinolone; armA; bla(OXA-23).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / microbiology*
  • Acinetobacter baumannii / classification
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • China
  • Cross Infection
  • Drug Resistance, Bacterial*
  • Drug Resistance, Multiple, Bacterial
  • Hospitals, University
  • Humans
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • Mutation
  • Phylogeny
  • Quinolones / pharmacology*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Quinolones
  • beta-Lactamases
  • beta-lactamase OXA-23, Acinetobacter baumannii