My oh my(osin): Insights into how auditory hair cells count, measure, and shape

Lana M Pollock; Shih-Wei Chou; Brian M McDermott Jr

doi:10.1083/jcb.201512086

My oh my(osin): Insights into how auditory hair cells count, measure, and shape

J Cell Biol. 2016 Jan 18;212(2):135-7. doi: 10.1083/jcb.201512086. Epub 2016 Jan 11.

Authors

Lana M Pollock¹, Shih-Wei Chou², Brian M McDermott Jr³

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
² Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 Department of Biology, Case Western Reserve University, Cleveland, OH 44106.
³ Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 Department of Biology, Case Western Reserve University, Cleveland, OH 44106 Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 [email protected].

Abstract

The mechanisms underlying mechanosensory hair bundle formation in auditory sensory cells are largely mysterious. In this issue, Lelli et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201509017) reveal that a pair of molecular motors, myosin IIIa and myosin IIIb, is involved in the hair bundle's morphology and hearing.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Hair Cells, Auditory / physiology*
Humans
Microvilli / physiology*
Myosin Heavy Chains / physiology*
Myosin Type III / physiology*
Stereocilia / physiology*

Substances

Myosin Type III
Myosin Heavy Chains

Abstract

Publication types

MeSH terms

Substances

Grants and funding