Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

Adham Jammoul; Yuebing Li; Alexander Rae-Grant

doi:10.3949/ccjm.83a.14112

Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable

Cleve Clin J Med. 2016 Jan;83(1):43-53. doi: 10.3949/ccjm.83a.14112.

Authors

Adham Jammoul¹, Yuebing Li², Alexander Rae-Grant^{3

4}

Affiliations

¹ Neurohospitalist Program, Department of Specialty Medicine, Aultman Hospital, Canton, OH, USA. E-mail: [email protected].
² Neuromuscular Center, Cleveland Clinic, Cleveland, OH, USA.
³ Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
⁴ Clinical Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.

PMID: 26760522
DOI: 10.3949/ccjm.83a.14112

Abstract

Autoantibody-mediated encephalitis is a heterogeneous group of recently identified disorders, all caused by autoimmunity directed against components of the central nervous system. Despite severe and even prolonged neurologic deficits, dramatic improvements may occur with aggressive treatment.

Publication types

Case Reports
Review

MeSH terms

Aged
Autoantibodies / blood*
Brain Stem
Cerebellum
Encephalitis / diagnosis*
Encephalitis / immunology*
Encephalitis / therapy
Female
Humans
Intracellular Signaling Peptides and Proteins
Limbic Encephalitis / immunology
Paraneoplastic Syndromes, Nervous System / diagnosis
Paraneoplastic Syndromes, Nervous System / immunology*
Positron-Emission Tomography
Potassium Channels, Voltage-Gated / immunology
Proteins / immunology*
Receptors, N-Methyl-D-Aspartate / immunology

Substances

Autoantibodies
Intracellular Signaling Peptides and Proteins
LGI1 protein, human
Potassium Channels, Voltage-Gated
Proteins
Receptors, N-Methyl-D-Aspartate