Evaluation of Xpert MTB/RIF for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid

F Pink; T J Brown; K Kranzer; F Drobniewski

doi:10.1128/JCM.02806-15

Evaluation of Xpert MTB/RIF for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid

J Clin Microbiol. 2016 Mar;54(3):809-11. doi: 10.1128/JCM.02806-15. Epub 2016 Jan 13.

Authors

F Pink¹, T J Brown², K Kranzer³, F Drobniewski⁴

Affiliations

¹ Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom [email protected].
² NMRL, Public Health England, London, United Kingdom.
³ NMRL, Public Health England, London, United Kingdom Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom National Mycobacterium Reference Laboratory, Research Centre Borstel, Borstel, Germany.
⁴ Department of Infection, Barts Health, London, United Kingdom NMRL, Public Health England, London, United Kingdom Department of Infectious Diseases, Imperial College, London, United Kingdom.

Abstract

Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary samples. The overall sensitivity was calculated at 55%.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Cerebrospinal Fluid / microbiology*
Child
Child, Preschool
Drug Resistance, Bacterial*
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Molecular Diagnostic Techniques*
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / genetics*
Reagent Kits, Diagnostic
Rifampin / pharmacology*
Sensitivity and Specificity
Tuberculosis, Central Nervous System / diagnosis*
Tuberculosis, Central Nervous System / microbiology*
Young Adult

Substances

Reagent Kits, Diagnostic
Rifampin