A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole

Claire Lee; Ian Mangion

doi:10.1016/j.jpba.2015.12.028

A GC-FID method for quantitative analysis of N,N-carbonyldiimidazole

J Pharm Biomed Anal. 2016 Mar 20:121:1-5. doi: 10.1016/j.jpba.2015.12.028. Epub 2015 Dec 21.

Authors

Claire Lee¹, Ian Mangion²

Affiliations

¹ Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, United States. Electronic address: [email protected].
² Department of Process and Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, United States. Electronic address: [email protected].

PMID: 26773533
DOI: 10.1016/j.jpba.2015.12.028

Abstract

N,N-Carbonyldiimidazole (CDI), a common synthetic reagent used in commercial scale pharmaceutical synthesis, is known to be sensitive to hydrolysis from ambient moisture. This liability demands a simple, robust analytical method to quantitatively determine reagent quality to ensure reproducible performance in chemical reactions. This work describes a protocol for a rapid GC-FID based analysis of CDI.

Keywords: CDI; Derivatization; GC; N,N-Carbonyldiimidazole.

MeSH terms

Chromatography, Gas / methods*
Flame Ionization / methods*
Imidazoles / chemistry*
Indicators and Reagents / chemistry
Pharmaceutical Preparations / chemistry

Substances

Imidazoles
Indicators and Reagents
Pharmaceutical Preparations
N,N-carbonyldiimidazole