Myelodysplastic syndromes with single neutropenia or thrombocytopenia are rarely refractory cytopenias with unilineage dysplasia by World Health Organization 2008 criteria and have favourable prognosis

Emmanuel Gyan; Valérie Andrieu; Alessandro Sanna; Agnès Caille; Jennifer Schemenau; Isabelle Sudaka; Virginie Siguret; Michèle Malet; Sophie Park; Dominique Bordessoule; Jacques Mairesse; Véronique Gelsi-Boyer; Stéphane Cheze; Odile Beyne-Rauzy; Marie Sébert; Rosa Sapena; Hacene Zerazhi; Laurence Legros; Agnès Guerci-Bresler; Shanti Natarjan Amé; Ulrich Germing; Valeria Santini; Flavia Salvi; Daniela Gioia; Monia Lunghi; François Dreyfus; Pierre Fenaux; Groupe Francophone des Myélodysplasies, Fondazione Italiana per le Sindromi Mielodisplastiche (FISMonlus), and Düsseldorf MDS Registry

doi:10.1111/bjh.13902

Myelodysplastic syndromes with single neutropenia or thrombocytopenia are rarely refractory cytopenias with unilineage dysplasia by World Health Organization 2008 criteria and have favourable prognosis

Br J Haematol. 2016 Dec;175(5):975-979. doi: 10.1111/bjh.13902. Epub 2016 Jan 15.

Authors

Emmanuel Gyan^{1

2}, Valérie Andrieu³, Alessandro Sanna⁴, Agnès Caille^{5

6

7}, Jennifer Schemenau⁸, Isabelle Sudaka⁹, Virginie Siguret¹⁰, Michèle Malet¹¹, Sophie Park¹², Dominique Bordessoule¹³, Jacques Mairesse¹⁴, Véronique Gelsi-Boyer¹⁵, Stéphane Cheze¹⁶, Odile Beyne-Rauzy¹⁷, Marie Sébert¹⁸, Rosa Sapena¹⁹, Hacene Zerazhi²⁰, Laurence Legros²¹, Agnès Guerci-Bresler²², Shanti Natarjan Amé²³, Ulrich Germing⁸, Valeria Santini⁴, Flavia Salvi²⁴, Daniela Gioia²⁵, Monia Lunghi²⁶, François Dreyfus²⁷, Pierre Fenaux¹⁸; Groupe Francophone des Myélodysplasies, Fondazione Italiana per le Sindromi Mielodisplastiche (FISMonlus), and Düsseldorf MDS Registry

Affiliations

¹ Service d'hématologie et thérapie cellulaire, CHU de Tours, Tours, France.
² Faculté de Médecine, Université François-Rabelais, UMR CNRS 7292, Tours, France.
³ Département Hématologie et Immunologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris 7 University, Paris, France.
⁴ Unità Funzionale di Ematologia, Università degli Studi di Firenze, AOU Careggi, Florence, Italy.
⁵ INSERM, CIC 1415, Tours, France.
⁶ Université François-Rabelais de Tours, PRES Centre-Val de Loire Université, Tours, France.
⁷ CHU de Tours, Tours, France.
⁸ Department of Haematology, Oncology and Clinical Immunology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
⁹ Laboratoire d'hématologie, CHU de Nice, Hospital Cimiez, Nice, France.
¹⁰ Hématologie biologique - Hémostase - Thrombose, Hôpital Lariboisière, INSERM UMR-S-1140, AP-HP, Paris, France.
¹¹ Service d'hématologie biologique, CHU de Caen, Caen, France.
¹² Service d'hématologie, Centre Hospitalier Universitaire, Grenoble, France.
¹³ Service d'Hématologie, CHU Dupuytren et Faculté de Médecine, Limoges, France.
¹⁴ Clinique Saint Pierre d'Ottignies, Service de Biopathologie, Ottignies, Belgium.
¹⁵ Centre de Recherches en Cancérologie, Institut Paoli-Calmettes, Marseille, France.
¹⁶ Service d'hématologie, Centre Hospitalier Universitaire, Caen, France.
¹⁷ Service de Médecine Interne, Centre hospitalier universitaire, Toulouse, France.
¹⁸ Service d'Hématologie clinique, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris 7 University, Paris, France.
¹⁹ Groupe Francophone des Myélodysplasies, Hôpital Saint-Louis, AP-HP, Paris, France.
²⁰ Service d'onco-hématologie, Centre Hospitalier, Avignon, France.
²¹ Service d'hématologie clinique, Centre Hospitalier Universitaire, Nice, France.
²² Service d'hématologie CHU Brabois, Vandœuvre-lès-Nancy, France.
²³ Département d'Hématologie et d'Oncologie, Centre Hospitalier Universitaire, Strasbourg, France.
²⁴ Haematology Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
²⁵ Fondazione Italiana Sindromi Mielodisplastiche (FISM) Onlus, Alessandria, Italy.
²⁶ Haematology, AOU Maggiore della Carità, Novara, Italy.
²⁷ Service d'hématologie, Hôpital Cochin, AP-HP, Université Paris 5, Paris, France.

PMID: 26773632
DOI: 10.1111/bjh.13902

No abstract available

Keywords: MDS; classifications; diagnostic haematology; neutropenia; thrombocytopenia.

Publication types

Historical Article
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Female
History, 21st Century
Humans
Male
Middle Aged
Myelodysplastic Syndromes / blood
Myelodysplastic Syndromes / diagnosis*
Neutropenia / metabolism*
Prognosis
Thrombocytopenia / metabolism*
World Health Organization
Young Adult