Diagnostic strategy and timing of intervention in infected necrotizing pancreatitis: an international expert survey and case vignette study

HPB (Oxford). 2016 Jan;18(1):49-56. doi: 10.1016/j.hpb.2015.07.003. Epub 2015 Dec 20.

Abstract

Background: The optimal diagnostic strategy and timing of intervention in infected necrotizing pancreatitis is subject to debate. We performed a survey on these topics amongst a group of international expert pancreatologists.

Methods: An online survey including case vignettes was sent to 118 international pancreatologists. We evaluated the use and timing of fine needle aspiration (FNA), antibiotics, catheter drainage and (minimally invasive) necrosectomy.

Results: The response rate was 74% (N = 87). None of the respondents use FNA routinely, 85% selectively and 15% never. Most respondents (87%) use a step-up approach in patients with infected necrosis. Walled-off necrosis (WON) is considered a prerequisite for endoscopic drainage and percutaneous drainage by 66% and 12%, respectively. After diagnosing infected necrosis, 55% routinely postpone invasive interventions, whereas 45% proceed immediately to intervention. Lack of consensus about timing of intervention was apparent on day 14 with proven infected necrosis (58% intervention vs. 42% non-invasive) as well as on day 20 with only clinically suspected infected necrosis (59% intervention vs. 41% non-invasive).

Discussion: The step-up approach is the preferred treatment strategy in infected necrotizing pancreatitis amongst expert pancreatologists. There is no uniformity regarding the use of FNA and timing of intervention in the first 2-3 weeks of infected necrotizing pancreatitis.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Biopsy, Fine-Needle
  • Consensus
  • Drainage* / adverse effects
  • Drainage* / trends
  • Drug Administration Schedule
  • Health Care Surveys
  • Humans
  • International Cooperation
  • Pancreatectomy* / adverse effects
  • Pancreatectomy* / trends
  • Pancreatitis, Acute Necrotizing / diagnosis*
  • Pancreatitis, Acute Necrotizing / microbiology
  • Pancreatitis, Acute Necrotizing / therapy*
  • Practice Patterns, Physicians'* / trends
  • Predictive Value of Tests
  • Risk Factors
  • Surveys and Questionnaires
  • Time Factors
  • Time-to-Treatment* / trends

Substances

  • Anti-Bacterial Agents