Opsoclonus-Myoclonus Syndrome, Neuroblastoma, and Insulin-Dependent Diabetes Mellitus in a Child: A Unique Patient

Twinkle Ghia; Manoj Kanhangad; Angela Jane Alessandri; Glynis Price; Parshotam Gera; Lakshmi Nagarajan

doi:10.1016/j.pediatrneurol.2015.09.021

Opsoclonus-Myoclonus Syndrome, Neuroblastoma, and Insulin-Dependent Diabetes Mellitus in a Child: A Unique Patient

Pediatr Neurol. 2016 Feb:55:68-70. doi: 10.1016/j.pediatrneurol.2015.09.021. Epub 2015 Oct 23.

Authors

Twinkle Ghia¹, Manoj Kanhangad¹, Angela Jane Alessandri², Glynis Price³, Parshotam Gera⁴, Lakshmi Nagarajan⁵

Affiliations

¹ Department of Neurology, Princess Margaret Hospital, Perth, Western Australia, Australia.
² Department of Oncology, Princess Margaret Hospital, Perth, Western Australia, Australia.
³ Department of Endocrinology, Princess Margaret Hospital, Perth, Western Australia, Australia.
⁴ Department of Paediatric Surgery, Princess Margaret Hospital, Perth, Western Australia, Australia.
⁵ Department of Neurology, Princess Margaret Hospital, Perth, Western Australia, Australia; School of Paediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Perth, Western Australia, Australia. Electronic address: [email protected].

PMID: 26778146
DOI: 10.1016/j.pediatrneurol.2015.09.021

Abstract

Aim: We present a new and unique association of opsoclonus-myoclonus-ataxia syndrome with neuroblastoma and type 1 diabetes mellitus.

Patient description: This 17-month-old child presented with opsoclonus-myoclonus-ataxia syndrome. Investigations revealed a thoracic neuroblastoma. Eleven days later, she re-presented with diabetic ketoacidosis. The neuroblastoma was resected, and she was given immunotherapy. At 12 months' follow-up, her neurological signs and symptoms have significantly improved, but she continues to be insulin dependent.

Discussion: This child expands the clinical spectrum of autoimmune disorders associated with opsoclonus-myoclonus-ataxia syndrome.

Keywords: anti-GAD antibodies; neuroblastoma; opsoclonus myoclonus ataxia; type I diabetes mellitus.

Publication types

Case Reports

MeSH terms

Diabetes Mellitus, Type 1 / diagnosis*
Diabetes Mellitus, Type 1 / drug therapy
Female
Humans
Infant
Neuroblastoma / diagnosis*
Neuroblastoma / surgery
Opsoclonus-Myoclonus Syndrome / diagnosis*
Opsoclonus-Myoclonus Syndrome / drug therapy
Thoracic Neoplasms / diagnosis*
Thoracic Neoplasms / surgery