Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors

Marie-Aline Neveu; Vanesa Bol; Anne Bol; Vincent Grégoire; Bernard Gallez

doi:10.1007/978-1-4939-3023-4_25

Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors

Adv Exp Med Biol. 2016:876:201-207. doi: 10.1007/978-1-4939-3023-4_25.

Authors

Marie-Aline Neveu¹, Vanesa Bol², Anne Bol², Vincent Grégoire², Bernard Gallez³

Affiliations

¹ Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium.
² Radiation Oncology Department & Center for Molecular Imaging, Institute of Experimental and Clinical Research, Université Catholique de Louvain, Brussels, Belgium.
³ Biomedical Magnetic Resonance Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium. [email protected].

PMID: 26782213
DOI: 10.1007/978-1-4939-3023-4_25

Abstract

The influence of changes in tumor oxygenation (monitored by EPR oximetry) on the uptake of 18F-FDG tracer was evaluated using micro-PET in two different human tumor models. The 18F-FDG uptake was higher in hypoxic tumors compared to tumors that present a pO2 value larger than 10 mmHg.

Keywords: 18F-FDG; Carbogen; EPR; PET; Tumor oxygenation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Electron Spin Resonance Spectroscopy
Fluorodeoxyglucose F18*
Humans
Mice
Neoplasms / metabolism*
Oxygen / metabolism*
Positron-Emission Tomography

Substances

Fluorodeoxyglucose F18
Oxygen